Article In: cienciavitae
Influence of SPION Surface Coating on Magnetic Properties and Theranostic Profile
Molecules
— 2024 — MDPI AG
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Published in
04/17/2024
Abstract
<jats:p>This study aimed to develop multifunctional nanoplatforms for both cancer imaging and therapy using superparamagnetic iron oxide nanoparticles (SPIONs). Two distinct synthetic methods, reduction–precipitation (MR/P) and co-precipitation at controlled pH (MpH), were explored, including the assessment of the coating’s influence, namely dextran and gold, on their magnetic properties. These SPIONs were further functionalized with gadolinium to act as dual T1/T2 contrast agents for magnetic resonance imaging (MRI). Parameters such as size, stability, morphology, and magnetic behavior were evaluated by a detailed characterization analysis. To assess their efficacy in imaging and therapy, relaxivity and hyperthermia experiments were performed, respectively. The results revealed that both synthetic methods lead to SPIONs with similar average size, 9 nm. Mössbauer spectroscopy indicated that samples obtained from MR/P consist of approximately 11–13% of Fe present in magnetite, while samples obtained from MpH have higher contents of 33–45%. Despite coating and functionalization, all samples exhibited superparamagnetic behavior at room temperature. Hyperthermia experiments showed increased SAR values with higher magnetic field intensity and frequency. Moreover, the relaxivity studies suggested potential dual T1/T2 contrast agent capabilities for the coated SPpH-Dx-Au-Gd sample, thus demonstrating its potential in cancer diagnosis.</jats:p>
Publication details
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Publication version
VoR - Version of Record
Publisher
MDPI AG
Title of the publication container
Molecules
First page or article number
1824
Volume
29
Issue
8
ISSN
1420-3049
Fields of Science and Technology (FOS)
chemical-sciences - Chemical sciences
Publication language (ISO code)
eng - English
Alternative identifier (URI)
https://scholar.tecnico.ulisboa.pt/records/ggxjI3AT8sT9MzblJAVLbdukQWtQvRJXOhGZ
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