Artigo De: cienciavitae

Influence of SPION Surface Coating on Magnetic Properties and Theranostic Profile

Molecules

Maria Paula Cordeiro Crespo Cabral Campello Aboim de Barros2024MDPI AG

Informações chave

Autores:

Maria Paula Cordeiro Crespo Cabral Campello Aboim de Barros (Maria Paula Cordeiro Crespo Cabral Campello Aboim de Barros)

Publicado em

17/04/2024

Resumo

<jats:p>This study aimed to develop multifunctional nanoplatforms for both cancer imaging and therapy using superparamagnetic iron oxide nanoparticles (SPIONs). Two distinct synthetic methods, reduction–precipitation (MR/P) and co-precipitation at controlled pH (MpH), were explored, including the assessment of the coating’s influence, namely dextran and gold, on their magnetic properties. These SPIONs were further functionalized with gadolinium to act as dual T1/T2 contrast agents for magnetic resonance imaging (MRI). Parameters such as size, stability, morphology, and magnetic behavior were evaluated by a detailed characterization analysis. To assess their efficacy in imaging and therapy, relaxivity and hyperthermia experiments were performed, respectively. The results revealed that both synthetic methods lead to SPIONs with similar average size, 9 nm. Mössbauer spectroscopy indicated that samples obtained from MR/P consist of approximately 11–13% of Fe present in magnetite, while samples obtained from MpH have higher contents of 33–45%. Despite coating and functionalization, all samples exhibited superparamagnetic behavior at room temperature. Hyperthermia experiments showed increased SAR values with higher magnetic field intensity and frequency. Moreover, the relaxivity studies suggested potential dual T1/T2 contrast agent capabilities for the coated SPpH-Dx-Au-Gd sample, thus demonstrating its potential in cancer diagnosis.</jats:p>

Detalhes da publicação

Autores da comunidade :

Versão da publicação

VoR - Versão publicada

Editora

MDPI AG

Título do contentor da publicação

Molecules

Primeira página ou número de artigo

1824

Volume

29

Fascículo

8

ISSN

1420-3049

Domínio Científico (FOS)

chemical-sciences - Química

Idioma da publicação (código ISO)

eng - Inglês

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