Artigo De: orcid, cienciavitae

Drug Formulations for Localized Treatment of Human Papillomavirus-Induced Lesions

Journal of Pharmaceutical Sciences

Izamara Gomes Maocha; Josué Carvalho; Carla Cruz — 2022 — Elsevier

Informações chave

Autores:

Izamara Gomes Maocha; Josué Carvalho; Jéssica Lopes-Nunes; Tiago Rosado; Eugénia Gallardo; Mariana Tomás; Ana Palmeira-de-Oliveira; Rita Palmeira-de-Oliveira; José Martinez-de-Oliveira; Maria Paula Cabral Campello (Maria Paula Cordeiro Crespo Cabral Campello Aboim de Barros); António Paulo (António Manuel Rocha Paulo); Carla Cruz

Publicado em

01/02/2022

Resumo

Background The human papillomavirus (HPV) is responsible for over 90% of all cervical cancer cases. The use of vaginal gels is often indicated for local vaginal drug delivery. Previous studies have shown that Thymus vulgaris essential oil (TEO) exhibits anticancer properties besides antifungal and antibacterial properties. Its activity derives from a specific increase in free radicals and oxidative stress caused in cancer cells. Furthermore, mitoxantrone (MTX), an anthracenedione, and C8, an acridine orange derivative, were shown to inhibit the growth of the cervical cancer cell line HeLa. Results The results showed that TEO + C8 is the most promising formulation in terms of viscosity and osmolality properties in vaginal fluid simulant (VFS). The combined action of TEO with the compounds MTX and C8 resulted in HeLa cell viability reduction compared with the effect obtained with the individual formulations containing each one of the compounds. Conclusions The formulation TEO + C8 holds promise in terms of cost-benefit and topical application of the active compound for the HeLa cells.

Detalhes da publicação

Autores da comunidade :

Versão da publicação

AO - Versão original do autor

Editora

Elsevier

Ligação para a versão da editora

https://jpharmsci.org/home

Título do contentor da publicação

Journal of Pharmaceutical Sciences

Primeira página ou número de artigo

2230

Última página

2238

Volume

111

Fascículo

8

ISSN

0022-3549

DOI

10.1016/j.xphs.2022.02.004

WoS (Web of Science)

WOS:000829687700011

Domínio Científico (FOS)

health-biotechnology - Biotecnologia Médica

Palavras-chave

  • Thyme
  • Human papillomavirus
  • Mitoxantrone
  • Acridine Orange derivative
  • Vaginal Formulation

Idioma da publicação (código ISO)

eng - Inglês

Identificador alternativo (URI)

http://dx.doi.org/10.1016/j.xphs.2022.02.004

Acesso à publicação:

Acesso apenas a metadados

Licença Creative Commons

CC-BY - CC-BY