Article In: orcid, cienciavitae

Drug Formulations for Localized Treatment of Human Papillomavirus-Induced Lesions

Journal of Pharmaceutical Sciences

Izamara Gomes Maocha; Josué Carvalho; Carla Cruz — 2022 — Elsevier

Key information

Authors:

Izamara Gomes Maocha; Josué Carvalho; Jéssica Lopes-Nunes; Tiago Rosado; Eugénia Gallardo; Mariana Tomás; Ana Palmeira-de-Oliveira; Rita Palmeira-de-Oliveira; José Martinez-de-Oliveira; Maria Paula Cabral Campello (Maria Paula Cordeiro Crespo Cabral Campello Aboim de Barros); António Paulo (António Manuel Rocha Paulo); Carla Cruz

Published in

02/01/2022

Abstract

Background The human papillomavirus (HPV) is responsible for over 90% of all cervical cancer cases. The use of vaginal gels is often indicated for local vaginal drug delivery. Previous studies have shown that Thymus vulgaris essential oil (TEO) exhibits anticancer properties besides antifungal and antibacterial properties. Its activity derives from a specific increase in free radicals and oxidative stress caused in cancer cells. Furthermore, mitoxantrone (MTX), an anthracenedione, and C8, an acridine orange derivative, were shown to inhibit the growth of the cervical cancer cell line HeLa. Results The results showed that TEO + C8 is the most promising formulation in terms of viscosity and osmolality properties in vaginal fluid simulant (VFS). The combined action of TEO with the compounds MTX and C8 resulted in HeLa cell viability reduction compared with the effect obtained with the individual formulations containing each one of the compounds. Conclusions The formulation TEO + C8 holds promise in terms of cost-benefit and topical application of the active compound for the HeLa cells.

Publication details

Authors in the community:

Publication version

AO - Author's Original

Publisher

Elsevier

Link to the publisher's version

https://jpharmsci.org/home

Title of the publication container

Journal of Pharmaceutical Sciences

First page or article number

2230

Last page

2238

Volume

111

Issue

8

ISSN

0022-3549

DOI

10.1016/j.xphs.2022.02.004

WoS (Web of Science)

WOS:000829687700011

Fields of Science and Technology (FOS)

health-biotechnology - Medical biotechnology

Keywords

  • Thyme
  • Human papillomavirus
  • Mitoxantrone
  • Acridine Orange derivative
  • Vaginal Formulation

Publication language (ISO code)

eng - English

Alternative identifier (URI)

http://dx.doi.org/10.1016/j.xphs.2022.02.004

Rights type:

Only metadata available

Creative Commons license

CC-BY - CC-BY