Artigo De: orcid, cienciavitae
Drug Formulations for Localized Treatment of Human Papillomavirus-Induced Lesions
Journal of Pharmaceutical Sciences
2022 — Elsevier
—Informações chave
Autores:
Publicado em
01/02/2022
Resumo
Background The human papillomavirus (HPV) is responsible for over 90% of all cervical cancer cases. The use of vaginal gels is often indicated for local vaginal drug delivery. Previous studies have shown that Thymus vulgaris essential oil (TEO) exhibits anticancer properties besides antifungal and antibacterial properties. Its activity derives from a specific increase in free radicals and oxidative stress caused in cancer cells. Furthermore, mitoxantrone (MTX), an anthracenedione, and C8, an acridine orange derivative, were shown to inhibit the growth of the cervical cancer cell line HeLa. Results The results showed that TEO + C8 is the most promising formulation in terms of viscosity and osmolality properties in vaginal fluid simulant (VFS). The combined action of TEO with the compounds MTX and C8 resulted in HeLa cell viability reduction compared with the effect obtained with the individual formulations containing each one of the compounds. Conclusions The formulation TEO + C8 holds promise in terms of cost-benefit and topical application of the active compound for the HeLa cells.
Detalhes da publicação
Autores da comunidade :
António Manuel Rocha Paulo
ist126677
Versão da publicação
AO - Versão original do autor
Editora
Elsevier
Ligação para a versão da editora
https://jpharmsci.org/home
Título do contentor da publicação
Journal of Pharmaceutical Sciences
Primeira página ou número de artigo
2230
Última página
2238
Volume
111
Fascículo
8
ISSN
0022-3549
WoS (Web of Science)
Domínio Científico (FOS)
health-biotechnology - Biotecnologia Médica
Palavras-chave
- Thyme
- Human papillomavirus
- Mitoxantrone
- Acridine Orange derivative
- Vaginal Formulation
Idioma da publicação (código ISO)
eng - Inglês
Identificador alternativo (URI)
http://dx.doi.org/10.1016/j.xphs.2022.02.004
Acesso à publicação:
Acesso apenas a metadados
Licença Creative Commons
CC-BY - CC-BY