Article In: orcid, cienciavitae

Radiolabeled Gold Nanoparticles for Imaging and Therapy of Cancer

Materials

Francisco Silva; Maria Paula Cabral Campello; António Paulo — 2021 — MDPI

Key information

Authors:

Francisco Silva; Maria Paula Cabral Campello (Maria Paula Cordeiro Crespo Cabral Campello Aboim de Barros); António Paulo (António Manuel Rocha Paulo)

Published in

01/02/2021

Abstract

first_pagesettingsOrder Article Reprints Open AccessReview Radiolabeled Gold Nanoparticles for Imaging and Therapy of Cancer by Francisco Silva 1,Maria Paula Cabral Campello 1,2 andAntónio Paulo 1,2,*ORCID 1 CTN—Centro de Ciências e Tecnologias Nucleares, Instituto Superior Técnico, Universidade de Lisboa, Estrada Nacional 10 (km 139,7), 2695-066 Bobadela, Portugal 2 DECN—Departamento de Engenharia e Ciências Nucleares, Instituto Superior Técnico, Universidade de Lisboa, Estrada Nacional 10 (km 139,7), 2695-066 Bobadela, Portugal * Author to whom correspondence should be addressed. Materials 2021, 14(1), 4; https://doi.org/10.3390/ma14010004 Received: 1 December 2020 / Revised: 16 December 2020 / Accepted: 18 December 2020 / Published: 22 December 2020 (This article belongs to the Special Issue Targeted Drug Delivery) Download Browse Figures Versions Notes Abstract In the Last decades, nanotechnology has provided novel and alternative methodologies and tools in the field of medical oncology, in order to tackle the issues regarding the control and treatment of cancer in modern society. In particular, the use of gold nanoparticles (AuNPs) in radiopharmaceutical development has provided various nanometric platforms for the delivery of medically relevant radioisotopes for SPECT/PET diagnosis and/or radionuclide therapy. In this review, we intend to provide insight on the methodologies used to obtain and characterize radiolabeled AuNPs while reporting relevant examples of AuNPs developed during the last decade for applications in nuclear imaging and/or radionuclide therapy, and highlighting the most significant preclinical studies and results.

Publication details

Authors in the community:

Publisher

MDPI

Link to the publisher's version

https://www.mdpi.com/journal/materials

Title of the publication container

Materials

First page or article number

4

Volume

14

Issue

1

ISSN

1996-1944

DOI

10.3390/ma14010004

WoS (Web of Science)

WOS:000606309000001

Fields of Science and Technology (FOS)

chemical-sciences - Chemical sciences

Keywords

  • gold nanoparticles (AuNPs)
  • nuclear imaging
  • radionuclide therapy
  • nanomedicine
  • nanotechnology

Publication language (ISO code)

eng - English

Alternative identifier (URI)

http://dx.doi.org/10.3390/ma14010004

Rights type:

Open access

Creative Commons license

CC-BY - CC-BY