Radiolabeled Gold Nanoparticles for Imaging and Therapy of Cancer

02/01/2021

first_pagesettingsOrder Article Reprints Open AccessReview Radiolabeled Gold Nanoparticles for Imaging and Therapy of Cancer by Francisco Silva 1,Maria Paula Cabral Campello 1,2 andAntónio Paulo 1,2,*ORCID 1 CTN—Centro de Ciências e Tecnologias Nucleares, Instituto Superior Técnico, Universidade de Lisboa, Estrada Nacional 10 (km 139,7), 2695-066 Bobadela, Portugal 2 DECN—Departamento de Engenharia e Ciências Nucleares, Instituto Superior Técnico, Universidade de Lisboa, Estrada Nacional 10 (km 139,7), 2695-066 Bobadela, Portugal * Author to whom correspondence should be addressed. Materials 2021, 14(1), 4; https://doi.org/10.3390/ma14010004 Received: 1 December 2020 / Revised: 16 December 2020 / Accepted: 18 December 2020 / Published: 22 December 2020 (This article belongs to the Special Issue Targeted Drug Delivery) Download Browse Figures Versions Notes Abstract In the Last decades, nanotechnology has provided novel and alternative methodologies and tools in the field of medical oncology, in order to tackle the issues regarding the control and treatment of cancer in modern society. In particular, the use of gold nanoparticles (AuNPs) in radiopharmaceutical development has provided various nanometric platforms for the delivery of medically relevant radioisotopes for SPECT/PET diagnosis and/or radionuclide therapy. In this review, we intend to provide insight on the methodologies used to obtain and characterize radiolabeled AuNPs while reporting relevant examples of AuNPs developed during the last decade for applications in nuclear imaging and/or radionuclide therapy, and highlighting the most significant preclinical studies and results.

Autores da comunidade :

• 

  M

  Maria Paula Cordeiro Crespo Cabral Campello Aboim de Barros

  ist25375

  Afiliações e fontes

  IST > DECN

  Departamento de Engenharia e Ciências Nucleares

  IST > C2TN

  Centro de Ciências e Tecnologias Nucleares

  De: orcid

  ID: 90341646

  De: cienciavitae

  ID: 2457500

• 

  A

  António Manuel Rocha Paulo

  ist126677

  Afiliações e fontes

  IST > DECN

  Departamento de Engenharia e Ciências Nucleares

  IST > C2TN

  Centro de Ciências e Tecnologias Nucleares

  De: orcid

  ID: 85704921

  De: cienciavitae

  ID: 2194438

MDPI

https://www.mdpi.com/journal/materials

Materials

4

14

1

1996-1944

10.3390/ma14010004

WOS:000606309000001

chemical-sciences - Química

Palavras-chave

• gold nanoparticles (AuNPs)
• nuclear imaging
• radionuclide therapy
• nanomedicine
• nanotechnology

eng - Inglês

http://dx.doi.org/10.3390/ma14010004

CC-BY - CC-BY