Article In: scopus, orcid, cienciavitae

Novel heterobimetallic radiotheranostic: Preparation, activity, and biodistribution

ChemMedChem

Adriaenssens, L.; Liu, Q.; Bodio, E. — 2014 — European Chemical Societies Publishing

Key information

Authors:

Adriaenssens, L.; Liu, Q.; Chaux-Picquet, F.; Tasan, S.; Picquet, M. (Maria Paula Cordeiro Crespo Cabral Campello Aboim de Barros); Denat, F.; Le Gendre, P.; Marques, F. (Fernanda Marujo Marques); Fernandes, C. (Célia Maria Da Cruz Fernandes); Mendes, F. (Filipa Fernandes Mendes); Gano, L. (Maria de Lurdes Barrela Patrício Gano); Campello, M.P.C.; Bodio, E.

Published in

01/01/2014

Abstract

A novel RuII(arene) theranostic complex is presented. It is based on a 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid macrocycle bearing a triarylphosphine and can be tracked in vivo by using the γ emission of 153Sm atoms. Notably, the heteroditopic ligand can be selectively metalated with ruthenium at the phosphorus atom despite the presence of other functionalities that are prone to metal coordination. Subsequent labeling with radionuclides such as 153Sm can then be performed easily. The resulting heterobimetallic complex exhibits favorable solubility and stability properties in biologically relevant media. It also shows in vitro cytotoxicity in line with that expected for this type of metallodrug, and is nontoxic to the organism as a whole. As a proof of concept, initial studies in healthy mice were performed to obtain information about the uptake, biodistribution, and excretion of the radiolabeled complex.

Publication details

Authors in the community:

Publication version

AO - Author's Original

Publisher

European Chemical Societies Publishing

Title of the publication container

ChemMedChem

First page or article number

1567

Last page

1573

Volume

9

Issue

7

DOI

10.1002/cmdc.201300494

WoS (Web of Science)

WOS:000338991100025

Fields of Science and Technology (FOS)

chemical-sciences - Chemical sciences

Publication language (ISO code)

eng - English

Alternative identifier (URI)

http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000338991100025&KeyUID=WOS:000338991100025

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