Artigo De: scopus, orcid, cienciavitae
Novel heterobimetallic radiotheranostic: Preparation, activity, and biodistribution
ChemMedChem
2014 — European Chemical Societies Publishing
—Informações chave
Autores:
Publicado em
01/01/2014
Resumo
A novel RuII(arene) theranostic complex is presented. It is based on a 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid macrocycle bearing a triarylphosphine and can be tracked in vivo by using the γ emission of 153Sm atoms. Notably, the heteroditopic ligand can be selectively metalated with ruthenium at the phosphorus atom despite the presence of other functionalities that are prone to metal coordination. Subsequent labeling with radionuclides such as 153Sm can then be performed easily. The resulting heterobimetallic complex exhibits favorable solubility and stability properties in biologically relevant media. It also shows in vitro cytotoxicity in line with that expected for this type of metallodrug, and is nontoxic to the organism as a whole. As a proof of concept, initial studies in healthy mice were performed to obtain information about the uptake, biodistribution, and excretion of the radiolabeled complex.
Detalhes da publicação
Autores da comunidade :
Fernanda Marujo Marques
ist25359
Célia Maria Da Cruz Fernandes
ist25452
Filipa Fernandes Mendes
ist25493
Versão da publicação
AO - Versão original do autor
Editora
European Chemical Societies Publishing
Título do contentor da publicação
ChemMedChem
Primeira página ou número de artigo
1567
Última página
1573
Volume
9
Fascículo
7
WoS (Web of Science)
Domínio Científico (FOS)
chemical-sciences - Química
Idioma da publicação (código ISO)
eng - Inglês
Identificador alternativo (URI)
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000338991100025&KeyUID=WOS:000338991100025
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