Artigo De: orcid, cienciavitae
In vitro and in vivo trackable titanocene-based complexes using optical imaging or SPECT
Dalton Transactions
2017 — Royal Society of Chemistry
—Informações chave
Autores:
Publicado em
2017
Resumo
A novel Ti/111In-heterometallic radiotheranostic along with non-radioactive Ti/In, Ti/Lu, and Ti/Y analogues has been reported, thanks to the design of a challenging synthesis of the first titanocene-DOTA ligand. The corresponding titanocene-BODIPY complex was developed for in vitro tracking by optical imaging. The different complexes were characterized and their antiproliferative properties were evaluated on three cancer cell lines (A2780, B16F1, and PC3). As a proof of concept, initial studies in healthy mice were performed with a Ti/111In derivative to obtain information about its uptake, its biodistribution, and its excretion. Confocal microscopy experiments were performed with fluorescent complexes to track it in vitro.
Detalhes da publicação
Autores da comunidade :
Fernanda Marujo Marques
ist25359
Versão da publicação
AO - Versão original do autor
Editora
Royal Society of Chemistry
Ligação para a versão da editora
https://pubs.rsc.org/en/journals/journal/dt
Título do contentor da publicação
Dalton Transactions
Primeira página ou número de artigo
14548
Última página
14555
Volume
46
Fascículo
42
WoS (Web of Science)
Domínio Científico (FOS)
health-sciences - Ciências de Saúde
Idioma da publicação (código ISO)
eng - Inglês
Identificador alternativo (URI)
https://doi.org/10.1039/C7DT01981E
Acesso à publicação:
Acesso apenas a metadados