Article In: scopus, orcid, cienciavitae

Local Response of Sialoliths to Lithotripsy: Cues on Fragmentation Outcome

Microscopy and Microanalysis

Manuel Francisco Costa Pereira; Infante, V. — 2017 — Oxford University Press (OUP)

Key information

Authors:

Manuel Francisco Costa Pereira (Manuel Francisco Costa Pereira); Infante, V. (Virgínia Isabel Monteiro Nabais Infante)

Published in

06/01/2017

Abstract

<jats:title>Abstract</jats:title><jats:p>Lithotripsy methods show relatively low efficiency in the fragmentation of sialoliths compared with the success rates achieved in the destruction of renal calculi. However, the information available on the mechanical behavior of sialoliths is limited and their apparently tougher response is not fully understood. This work evaluates the hardness and Young’s modulus of sialoliths at different scales and analyzes specific damage patterns induced in these calcified structures by ultrasonic vibrations, pneumoballistic impacts, shock waves, and laser ablation. A clear correlation between local mechanical properties and ultrastructure/chemistry has been established: sialoliths are composite materials consisting of hard and soft components of mineralized and organic nature, respectively. Ultrasonic and pneumoballistic reverberations damage preferentially highly mineralized regions, leaving relatively unaffected the surrounding organic matter. In contrast, shock waves leach the organic component and lead to erosion of the overall structure. Laser ablation destroys homogeneously the irradiated zones regardless of the mineralized/organic nature of the underlying ultrastructure; however, damage is less extensive than with mechanical methods. Overall, the present results show that composition and internal structure are key features behind sialoliths’ comminution behavior and that the organic matter contributes to reduce the therapeutic efficiency of lithotripsy methods.</jats:p>

Publication details

Authors in the community:

Publication version

VoR - Version of Record

Publisher

Oxford University Press (OUP)

Title of the publication container

Microscopy and Microanalysis

First page or article number

584

Last page

598

Volume

23

Issue

3

ISSN

1431-9276

DOI

10.1017/S143192761700037X

Fields of Science and Technology (FOS)

earth-and-related-environmental-sciences - Earth and related environmental sciences

Keywords

  • Instrumentation

Publication language (ISO code)

eng - English

Alternative identifier (URI)

http://www.scopus.com/inward/record.url?eid=2-s2.0-85018853690&partnerID=MN8TOARS

Rights type:

Only metadata available