Synthesis, characterization and antitumor activity of two new dipyridinium ylide based lanthanide(III) complexes

Agosto 2018

Two new dinuclear lanthanide(III) complexes, La-DPY and Nd-DPY, with the stoichiometric formula [{Ln(Et3N)(SO4)}2(μ-DPY)(μ4-SO4)] (Ln = La, Nd; DPY = ylide form of DPB, Et3N = triethylamine), were obtained through the reaction of N-heterocylic diquaternary salt N,N’-diphenacyl-4,4′-dipyridinium dibromide (DPB) and lanthanide(III) sulfate in methanol, in the presence of triethylamine. The obtained complexes were characterized by Fourier transform infrared spectroscopy, proton nuclear magnetic resonance, elemental analysis, UV–vis spectroscopy, thermogravimetric analysis and powder X-ray diffraction. Scanning electron microscopy (SEM) was used to investigate the morphology and particles size of the complexes, confirming that their particles are quite homogenous and uniform. The antitumor activity of the complexes was evaluated in the human cancer cells MCF7 and A2780 and compared to cisplatin, the metal-based drug in cancer therapy. The complexes were found to induce apoptotic cell death and, to a lesser extent, production of ROS, although these are not the unique mechanisms of action. In conclusion, we anticipate that these types of Ln(III) complexes have potential and could be further explored for applications as antitumor agents.

Autores da comunidade :

• 

  F

  Fernanda Marujo Marques

  ist25359

  Afiliações e fontes

  IST > C2TN

  Centro de Ciências e Tecnologias Nucleares

  IST > DECN

  Departamento de Engenharia e Ciências Nucleares

• 

  M

  Maria Paula Cordeiro Crespo Cabral Campello Aboim de Barros

  ist25375

  Afiliações e fontes

  IST > C2TN

  Centro de Ciências e Tecnologias Nucleares

  IST > DECN

  Departamento de Engenharia e Ciências Nucleares

  De: orcid

  ID: 57882609

  De: cienciavitae

  ID: 1501049

AO - Versão original do autor

Elsevier

https://www.sciencedirect.com/journal/inorganica-chimica-acta

Inorganica Chimica Acta

83

90

480

0020-1693

10.1016/j.ica.2018.05.003

WOS:000436774400010

chemical-sciences - Química

Palavras-chave

• Trivalent lanthanide complexes
• Heterocyclic ligands
• Ylide
• Dipyridinium ylide
• Antitumor activity,

eng - Inglês

http://dx.doi.org/10.1016/j.ica.2018.05.003