Article In: orcid, cienciavitae

Synthesis, characterization and antitumor activity of two new dipyridinium ylide based lanthanide(III) complexes

Inorganica Chimica Acta

Cârâc, Andreea; Boscencu, Rica; et al — 2018 — Elsevier

Key information

Authors:

Cârâc, Andreea; Boscencu, Rica; Dinica, Rodica Mihaela; Guerreiro, Joana F.; Silva, Francisco; Marques, Fernanda (Fernanda Marujo Marques); Campello, Maria Paula Cabral (Maria Paula Cordeiro Crespo Cabral Campello Aboim de Barros); et al

Published in

August 2018

Abstract

Two new dinuclear lanthanide(III) complexes, La-DPY and Nd-DPY, with the stoichiometric formula [{Ln(Et3N)(SO4)}2(μ-DPY)(μ4-SO4)] (Ln = La, Nd; DPY = ylide form of DPB, Et3N = triethylamine), were obtained through the reaction of N-heterocylic diquaternary salt N,N’-diphenacyl-4,4′-dipyridinium dibromide (DPB) and lanthanide(III) sulfate in methanol, in the presence of triethylamine. The obtained complexes were characterized by Fourier transform infrared spectroscopy, proton nuclear magnetic resonance, elemental analysis, UV–vis spectroscopy, thermogravimetric analysis and powder X-ray diffraction. Scanning electron microscopy (SEM) was used to investigate the morphology and particles size of the complexes, confirming that their particles are quite homogenous and uniform. The antitumor activity of the complexes was evaluated in the human cancer cells MCF7 and A2780 and compared to cisplatin, the metal-based drug in cancer therapy. The complexes were found to induce apoptotic cell death and, to a lesser extent, production of ROS, although these are not the unique mechanisms of action. In conclusion, we anticipate that these types of Ln(III) complexes have potential and could be further explored for applications as antitumor agents.

Publication details

Authors in the community:

Publication version

AO - Author's Original

Publisher

Elsevier

Link to the publisher's version

https://www.sciencedirect.com/journal/inorganica-chimica-acta

Title of the publication container

Inorganica Chimica Acta

First page or article number

83

Last page

90

Volume

480

ISSN

0020-1693

DOI

10.1016/j.ica.2018.05.003

WoS (Web of Science)

WOS:000436774400010

Fields of Science and Technology (FOS)

chemical-sciences - Chemical sciences

Keywords

  • Trivalent lanthanide complexes
  • Heterocyclic ligands
  • Ylide
  • Dipyridinium ylide
  • Antitumor activity,

Publication language (ISO code)

eng - English

Alternative identifier (URI)

http://dx.doi.org/10.1016/j.ica.2018.05.003

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