Article In: orcid

Polyurea Dendrimer Folate-Targeted Nanodelivery of l-Buthionine sulfoximine as a Tool to Tackle Ovarian Cancer Chemoresistance

Antioxidants

Rita Figueiredo Pires — 2020

Key information

Authors:

Rita Figueiredo Pires (Rita Figueiredo Pires)

Published in

February 3, 2020

Abstract

<jats:p>: Ovarian cancer is a highly lethal disease, mainly due to chemoresistance. Our previous studies on metabolic remodeling in ovarian cancer have supported that the reliance on glutathione (GSH) bioavailability is a main adaptive metabolic mechanism, also accounting for chemoresistance to conventional therapy based on platinum salts. In this study, we tested the effects of the in vitro inhibition of GSH synthesis on the restoration of ovarian cancer cells sensitivity to carboplatin. GSH synthesis was inhibited by exposing cells to l-buthionine sulfoximine (l-BSO), an inhibitor of -glutamylcysteine ligase (GCL). Given the systemic toxicity of l-BSO, we developed a new formulation using polyurea (PURE) dendrimers nanoparticles (l-BSO@PUREG4-FA2), targeting l-BSO delivery in a folate functionalized nanoparticle.</jats:p>

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Title of the publication container

Antioxidants

ISSN

2076-3921

DOI

10.3390/antiox9020133

Fields of Science and Technology (FOS)

health-biotechnology - Medical biotechnology

Publication language (ISO code)

eng - English

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