Article
The supporting role of plasmids in gene & cell therapy
Cell & Gene Therapy Insights
— 2023
Key information
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Published in
2023
Abstract
The biopharmaceutical relevance of producing plasmid DNA at large scale has increased steadily over the years due to the development of a growing number of direct and indirect applications. Be it as biological drugs or as starting materials, plasmids are pervasive across the gene and cell therapy industry of today. With hundreds of biopharmaceutical companies using plasmids in the clinical development of their products, plasmid manufacturing is starting to emerge as a key bottleneck. This commentary provides an overview of the uses of plasmids, discusses manufacturing challenges, and hints at what the future may bring.
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https://d1wqtxts1xzle7.cloudfront.net/104161772/Prazeres_1018609cgti2023094-libre.pdf?1689000304=&response-content-disposition=attachment%3B+filename%3DThe_supporting_role_of_plasmids_in_gene.pdf&Expires=1690902009&Signature=CG4ytutbW2h-5dBuCVwXTAF9pofRBrTAgaWBhnJ409hmAiAPPpBQ0SDR6L-UDR8arsS-k2yDOO5kEv~Nkws6S2d0LGJ1jY6INuaiCVGkzv16kkJZVITiteuWiiSB696Kv98hHbO9-vYD01hDZn540sEIOCkIrF9E~ySUx3bZK4xwQ-igBtGTGIB2zAtBvzGQ3A8-aKuaFiFjvM1KrgZ2tyGcIji9~VIWpy~6Bo1ii61gPhxlhw-qyuaXpu~qbk3RFgf8vDdln3XvaYE0RSJ9FmAadqwZEyWQJTSINpCnshwM6F3tWoCB8qK2kujyQh1oWiBtLnm0E0tG7m0q-9fLFw__&Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA
Title of the publication container
Cell & Gene Therapy Insights
First page or article number
755
Last page
762
Volume
9
Issue
5
Fields of Science and Technology (FOS)
industrial-biotechnology - Industrial Biotechnology
Keywords
- Gene therapy
- Cell therapy
- Biomanufacturing
- Plasmid DNA
Publication language (ISO code)
eng - English
Rights type:
Open access