Article In: scopus

Comparison of two hydrogel formulations for drug release in ophthalmic lenses

Journal of Biomedical Materials Research - Part B Applied Biomaterials

Paradiso P.; Galante R.; Saramago B. — 2014 — Wiley

Key information

Authors:

Paradiso P. (Patrizia Paradiso); Galante R.; Santos L. (Luís Filipe da Silva dos Santos); Alves De Matos A.P.; Colaço R. (Rogério Anacleto Cordeiro Colaço); Serro A.P. (Ana Paula Valagão Amadeu do Serro); Saramago B. (Benilde de Jesus Vieira Saramago)

Published in

August 2014

Abstract

In the present work two types of polymers were investigated as drug releasing contact lens materials: a poly-hydroxyethylmethacrylate (pHEMA) based hydrogel and a silicone hydrogel. The silicone hydrogel resulted from the addition of TRIS, a hydrophobic monomer containing silicon (3-tris(trimethylsilyloxy)silylpropyl 2-methylprop-2-enoate), to pHEMA. Both hydrogels were loaded with an antibiotic (levofloxacin) and an antiseptic (chlorhexidine) by soaking in the drug solutions. The hydrogel properties were determined to be within the range demanded for lens materials. The release profiles of both drugs from the hydrogels were obtained and eventual drug/polymer interactions were assessed with the help of Raman spectra. A mathematical model, developed to mimic the eye conditions, was applied to the experimental results in order to predict the in vivo efficacy of the studied systems. The release profiles were compared with those resulting from the application of commercial eyedrops. The pHEMA based hydrogel demonstrated to be the best material to achieve a controlled release of levofloxacin. In the case of chlorhexidine, the silicone hydrogel seems to lead to better results. In both cases, our results suggest that these materials are adequate for the preparation of daily disposable therapeutic contact lenses. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 102B: 1170–1180, 2014.

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Publication version

VoR - Version of Record

Publisher

Wiley

Link to the publisher's version

https://onlinelibrary.wiley.com/doi/10.1002/jbm.b.33099

Title of the publication container

Journal of Biomedical Materials Research - Part B Applied Biomaterials

First page or article number

1170

Last page

1180

Volume

102

Issue

6

DOI

10.1002/jbm.b.33099

Fields of Science and Technology (FOS)

materials-engineering - Materials engineering

Keywords

  • controlled release
  • contact lens materials
  • pHEMA
  • silicone
  • levofloxacin
  • chlorhexidine

Publication language (ISO code)

eng - English

Rights type:

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