Artigo De: scopus

Comparison of two hydrogel formulations for drug release in ophthalmic lenses

Journal of Biomedical Materials Research - Part B Applied Biomaterials

Paradiso P.; Galante R.; Saramago B. — 2014 — Wiley

Informações chave

Autores:

Paradiso P. (Patrizia Paradiso); Galante R.; Santos L. (Luís Filipe da Silva dos Santos); Alves De Matos A.P.; Colaço R. (Rogério Anacleto Cordeiro Colaço); Serro A.P. (Ana Paula Valagão Amadeu do Serro); Saramago B. (Benilde de Jesus Vieira Saramago)

Publicado em

Agosto 2014

Resumo

In the present work two types of polymers were investigated as drug releasing contact lens materials: a poly-hydroxyethylmethacrylate (pHEMA) based hydrogel and a silicone hydrogel. The silicone hydrogel resulted from the addition of TRIS, a hydrophobic monomer containing silicon (3-tris(trimethylsilyloxy)silylpropyl 2-methylprop-2-enoate), to pHEMA. Both hydrogels were loaded with an antibiotic (levofloxacin) and an antiseptic (chlorhexidine) by soaking in the drug solutions. The hydrogel properties were determined to be within the range demanded for lens materials. The release profiles of both drugs from the hydrogels were obtained and eventual drug/polymer interactions were assessed with the help of Raman spectra. A mathematical model, developed to mimic the eye conditions, was applied to the experimental results in order to predict the in vivo efficacy of the studied systems. The release profiles were compared with those resulting from the application of commercial eyedrops. The pHEMA based hydrogel demonstrated to be the best material to achieve a controlled release of levofloxacin. In the case of chlorhexidine, the silicone hydrogel seems to lead to better results. In both cases, our results suggest that these materials are adequate for the preparation of daily disposable therapeutic contact lenses. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 102B: 1170–1180, 2014.

Detalhes da publicação

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Versão da publicação

VoR - Versão publicada

Editora

Wiley

Ligação para a versão da editora

https://onlinelibrary.wiley.com/doi/10.1002/jbm.b.33099

Título do contentor da publicação

Journal of Biomedical Materials Research - Part B Applied Biomaterials

Primeira página ou número de artigo

1170

Última página

1180

Volume

102

Fascículo

6

DOI

10.1002/jbm.b.33099

Domínio Científico (FOS)

materials-engineering - Engenharia dos Materiais

Palavras-chave

  • controlled release
  • contact lens materials
  • pHEMA
  • silicone
  • levofloxacin
  • chlorhexidine

Idioma da publicação (código ISO)

eng - Inglês

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