Artigo De: cienciavitae

Equilibria in Aqueous Cobalt(II)—reduced schiff base N-(2-hydroxybenzyl)alanine system: chemical characterization, kinetic analysis, antimicrobial and cytotoxic properties

Molecules

Magdalena Wozniczka; Manas Sutradhar; et al — 2020 — MDPI AG

Informações chave

Autores:

Magdalena Wozniczka; Manas Sutradhar (Manas Sutradhar); Armando J. L. Pombeiro; Miroslawa Swiatek; Marek Pajak; Joanna Gadek-Sobczynska; Magdalena Chmiela; et al

Publicado em

30/07/2020

Resumo

<jats:p>The present study describes the coordination properties of a reduced Schiff base, N-(2-hydroxybenzyl)alanine, towards cobalt(II) using potentiometric as well as spectroscopic (UV-Vis and ESI-MS) methods. The results indicate the formation of six mononuclear complexes showing high stability in aqueous solution. Coordination occurs in the {O−phenolic,N,O−carboxyl} and {N,O−carboxyl} chelation modes, depending on the degree of ligand deprotonation. Examination of the complexation equilibria at pH ca 7, which is important from a biological point of view, allowed to identify two species: [CoL] and [CoL2H]−. The kinetic analysis showed a structural change of those cobalt(II) complexes from octahedral to tetrahedral in accordance with a first-order time relationship. The antimicrobial properties of N-(2-hydroxybenzyl)alanine, cobalt(II) nitrate and of the Co(II) – ligand complexes were determined against Gram-positive bacteria (Enterococcus faecalis, Staphylococcus aureus, Staphylococcus epidermidis), Gram-negative bacteria (Pseudomonas aeruginosa, Escherichia coli, Helicobacter pylori) and a fungal strain (Candida). The results indicate that the complexes are more active for more strains than the ligand alone. Nevertheless, the complexes induce a higher decrease in the metabolic activity of cells but without damage to nuclei. Tetrahedral structures show stronger anti-cellular toxicity than octahedral complexes, which is most likely due to the higher accessibility of the cobalt(II) center.</jats:p>

Detalhes da publicação

Autores da comunidade :

Versão da publicação

VoR - Versão publicada

Editora

MDPI AG

Ligação para a versão da editora

https://www.mdpi.com/1420-3049/25/15/3462

Título do contentor da publicação

Molecules

Primeira página ou número de artigo

3462

Volume

25

Fascículo

15

ISSN

1420-3049

DOI

10.3390/molecules25153462

Domínio Científico (FOS)

chemical-sciences - Química

Palavras-chave

  • Chemistry (miscellaneous)
  • Analytical Chemistry
  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Molecular Medicine
  • Drug Discovery
  • Pharmaceutical Science
  • cobalt(II) complexes
  • coordination modes
  • reduced Schiff base
  • stability constant
  • biological activity
  • UV-Vis spectroscopy
  • ESI-MS

Idioma da publicação (código ISO)

eng - Inglês

Identificador alternativo (URI)

https://doi.org/10.3390/molecules25153462

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