Article In: cienciavitae

Equilibria in Aqueous Cobalt(II)—Reduced Schiff Base N-(2-hydroxybenzyl)alanine System: Chemical Characterization, Kinetic Analysis, Antimicrobial and Cytotoxic Properties

Molecules

Magdalena Wozniczka; Manas Sutradhar; et al — 2020 — MDPI AG

Key information

Authors:

Magdalena Wozniczka; Manas Sutradhar (Manas Sutradhar); Armando J. L. Pombeiro; Miroslawa Swiatek; Marek Pajak; Joanna Gadek-Sobczynska; Magdalena Chmiela; et al

Published in

07/30/2020

Abstract

<jats:p>The present study describes the coordination properties of a reduced Schiff base, N-(2-hydroxybenzyl)alanine, towards cobalt(II) using potentiometric as well as spectroscopic (UV-Vis and ESI-MS) methods. The results indicate the formation of six mononuclear complexes showing high stability in aqueous solution. Coordination occurs in the {O−phenolic,N,O−carboxyl} and {N,O−carboxyl} chelation modes, depending on the degree of ligand deprotonation. Examination of the complexation equilibria at pH ca 7, which is important from a biological point of view, allowed to identify two species: [CoL] and [CoL2H]−. The kinetic analysis showed a structural change of those cobalt(II) complexes from octahedral to tetrahedral in accordance with a first-order time relationship. The antimicrobial properties of N-(2-hydroxybenzyl)alanine, cobalt(II) nitrate and of the Co(II) – ligand complexes were determined against Gram-positive bacteria (Enterococcus faecalis, Staphylococcus aureus, Staphylococcus epidermidis), Gram-negative bacteria (Pseudomonas aeruginosa, Escherichia coli, Helicobacter pylori) and a fungal strain (Candida). The results indicate that the complexes are more active for more strains than the ligand alone. Nevertheless, the complexes induce a higher decrease in the metabolic activity of cells but without damage to nuclei. Tetrahedral structures show stronger anti-cellular toxicity than octahedral complexes, which is most likely due to the higher accessibility of the cobalt(II) center.</jats:p>

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Publication version

VoR - Version of Record

Publisher

MDPI AG

Title of the publication container

Molecules

First page or article number

3462

Volume

25

Issue

15

ISSN

1420-3049

DOI

10.3390/molecules25153462

Fields of Science and Technology (FOS)

chemical-sciences - Chemical sciences

Keywords

  • Chemistry (miscellaneous)
  • Analytical Chemistry
  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Molecular Medicine
  • Drug Discovery
  • Pharmaceutical Science

Publication language (ISO code)

eng - English

Alternative identifier (URI)

https://doi.org/10.3390/molecules25153462

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