Equilibria in Aqueous Cobalt(II)—Reduced Schiff Base N-(2-hydroxybenzyl)alanine System: Chemical Characterization, Kinetic Analysis, Antimicrobial and Cytotoxic Properties

30/07/2020

<jats:p>The present study describes the coordination properties of a reduced Schiff base, N-(2-hydroxybenzyl)alanine, towards cobalt(II) using potentiometric as well as spectroscopic (UV-Vis and ESI-MS) methods. The results indicate the formation of six mononuclear complexes showing high stability in aqueous solution. Coordination occurs in the {O−phenolic,N,O−carboxyl} and {N,O−carboxyl} chelation modes, depending on the degree of ligand deprotonation. Examination of the complexation equilibria at pH ca 7, which is important from a biological point of view, allowed to identify two species: [CoL] and [CoL2H]−. The kinetic analysis showed a structural change of those cobalt(II) complexes from octahedral to tetrahedral in accordance with a first-order time relationship. The antimicrobial properties of N-(2-hydroxybenzyl)alanine, cobalt(II) nitrate and of the Co(II) – ligand complexes were determined against Gram-positive bacteria (Enterococcus faecalis, Staphylococcus aureus, Staphylococcus epidermidis), Gram-negative bacteria (Pseudomonas aeruginosa, Escherichia coli, Helicobacter pylori) and a fungal strain (Candida). The results indicate that the complexes are more active for more strains than the ligand alone. Nevertheless, the complexes induce a higher decrease in the metabolic activity of cells but without damage to nuclei. Tetrahedral structures show stronger anti-cellular toxicity than octahedral complexes, which is most likely due to the higher accessibility of the cobalt(II) center.</jats:p>

Autores da comunidade :

• 

  M

  Manas Sutradhar

  ist34360

  Afiliações e fontes

  IST > CQE

  Centro de Química Estrutural

  De: cienciavitae

  ID: 2448674

VoR - Versão publicada

MDPI AG

Molecules

3462

25

15

1420-3049

10.3390/molecules25153462

chemical-sciences - Química

Palavras-chave

• Chemistry (miscellaneous)
• Analytical Chemistry
• Organic Chemistry
• Physical and Theoretical Chemistry
• Molecular Medicine
• Drug Discovery
• Pharmaceutical Science

eng - Inglês

https://doi.org/10.3390/molecules25153462