Non-coding regulatory sRNAs from bacteria of the Burkholderia cepacia complex

04/02/2024

<jats:sec> <jats:title>Abstract</jats:title> <jats:p>Small non-coding RNAs (sRNAs) are key regulators of post-transcriptional gene expression in bacteria. Hundreds of sRNAs have been found using in silico genome analysis and experimentally based approaches in bacteria of the <jats:italic>Burkholderia cepacia</jats:italic> complex (Bcc). However, and despite the hundreds of sRNAs identified so far, the number of functionally characterized sRNAs from these bacteria remains very limited. In this mini-review, we describe the general characteristics of sRNAs and the main mechanisms involved in their action as regulators of post-transcriptional gene expression, as well as the work done so far in the identification and characterization of sRNAs from Bcc. The number of functionally characterized sRNAs from Bcc is expected to increase and to add new knowledge on the biology of these bacteria, leading to novel therapeutic approaches to tackle the infections caused by these opportunistic pathogens, particularly severe among cystic fibrosis patients.</jats:p> </jats:sec><jats:sec> <jats:title>Key points</jats:title> <jats:p><jats:italic>•Hundreds of sRNAs have been identified in Burkholderia cepacia complex bacteria (Bcc).</jats:italic></jats:p> <jats:p><jats:italic>•A few sRNAs have been functionally characterized in Bcc.</jats:italic></jats:p> <jats:p><jats:italic>•Functionally characterized Bcc sRNAs play major roles in metabolism, biofilm formation, and virulence.</jats:italic></jats:p> </jats:sec>

Authors in the community:

• 

  J

  Jorge Humberto Gomes Leitão

  ist14034

  Affiliations and sources

  IST > iBB

  Instituto de Bioengenharia e Biociências

  IST > DBE

  Departamento de Bioengenharia

  In: orcid

  ID: 156760978

VoR - Version of Record

Springer Science and Business Media LLC

Applied Microbiology and Biotechnology

108

1

0175-7598

10.1007/s00253-024-13121-6

biological-sciences - Biological sciences

eng - English