A Multi-Technique Investigation of the Complex Formation Equilibria between Bis-Deferiprone Derivatives and Oxidovanadium (IV)

25/02/2022

The increasing biomedical interest in high-stability oxidovanadium(IV) complexes with hydroxypyridinone ligands leads us to investigate the complex formation equilibria of VIVO2+ ion with a tetradentate ligand, named KC21, which contains two 3-hydroxy-1,2-dimethylpyridin-4(1H)-one (deferiprone) moieties, and with the simple bidentate ligand that constitutes the basic unit of KC21, for comparison, named L5. These equilibrium studies were conducted with joined potentiometric– spectrophotometric titrations, and the results were substantiated with EPR measurements at variable pH values. This multi-technique study gave evidence of the formation of an extremely stable 1:1 complex between KC21 and oxidovanadium(IV) at a physiological pH, which could find promising pharmacological applications.

Autores da comunidade :

• 

  M

  Maria Amélia Loureiro dos Santos Seabra

  ist11207

  Afiliações e fontes

  IST > CQE

  Centro de Química Estrutural

  IST > DEQ

  Departamento de Engenharia Química

  De: orcid

  ID: 108939602

VoR - Versão publicada

MDPI

https://doi.org/10.3390/molecules27051555

Molecules

1555

27

10.3390/molecules27051555

chemical-sciences - Química

Palavras-chave

• Oxidovanadium (IV)
• Deferiprone
• Potentiometry; UV spectrophotometry
• EPR spectroscopy

eng - Inglês