Article In: orcid

A Multi-Technique Investigation of the Complex Formation Equilibria between Bis-Deferiprone Derivatives and Oxidovanadium (IV)

Molecules

Rosita Cappai; Alessandra Fantasia; Valeria Marina Nurchi — 2022 — MDPI

Key information

Authors:

Rosita Cappai; Alessandra Fantasia; Guido Crisponi; Eugenio Garribba; M. Amélia Santos (Maria Amélia Loureiro dos Santos Seabra); Valeria Marina Nurchi

Published in

02/25/2022

Abstract

The increasing biomedical interest in high-stability oxidovanadium(IV) complexes with hydroxypyridinone ligands leads us to investigate the complex formation equilibria of VIVO2+ ion with a tetradentate ligand, named KC21, which contains two 3-hydroxy-1,2-dimethylpyridin-4(1H)-one (deferiprone) moieties, and with the simple bidentate ligand that constitutes the basic unit of KC21, for comparison, named L5. These equilibrium studies were conducted with joined potentiometric– spectrophotometric titrations, and the results were substantiated with EPR measurements at variable pH values. This multi-technique study gave evidence of the formation of an extremely stable 1:1 complex between KC21 and oxidovanadium(IV) at a physiological pH, which could find promising pharmacological applications.

Publication details

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Publication version

VoR - Version of Record

Publisher

MDPI

Link to the publisher's version

https://doi.org/10.3390/molecules27051555

Title of the publication container

Molecules

First page or article number

1555

Volume

27

DOI

10.3390/molecules27051555

Fields of Science and Technology (FOS)

chemical-sciences - Chemical sciences

Keywords

  • Oxidovanadium (IV)
  • Deferiprone
  • Potentiometry; UV spectrophotometry
  • EPR spectroscopy

Publication language (ISO code)

eng - English

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