A multifunctional Schiff base: investigating its Zirconium sensing capabilities and antiproliferative effects

Janeiro 2026

The current investigation is focused on the synthesis of indole-3-carboxaldehyde functionalized Schiff base 5, which was characterized via X-ray crystallographic study, 1H NMR spectroscopy, 13C NMR spectroscopy, FT-IR spectroscopy, mass spectrometry (LCMS) and thermal gravimetric analysis (TGA). Compound 5 has been identified as an effective and highly selective Zr(IV) sensor using UV–Visible spectroscopy with a limit of detection (LOD) 3.7 × 10–7 M. Compound 5 exhibited the most significant anticancer activity, reducing cell viability by upto 67.67 % compared to untreated control cells. Experiments on Cajanus cajan (pigeon pea) seeds revealed its efficacy as a good plant growth regulator. Molecular docking studies further supported its therapeutic potential by revealing strong interactions with both an anticancer target protein and a plant gibberellin protein, indicating its dual role as potential anticancer agent and a plant growth regulator. The findings from the study provides the foundation for future research into zirconium sensing and anticancer applications, potentially leading to the development of new sensors and anticancer drugs.

Autores da comunidade :

• 

  B

  Brij Mohan

  ist429533

  Afiliações e fontes

  IST > CQE

  Centro de Química Estrutural

  De: orcid

  ID: 192318666

Elsevier

https://www.sciencedirect.com/science/article/pii/S002228602502695X?via%3Dihub

Journal of Molecular Structure

1350

10.1016/j.molstruc.2025.144049

chemical-engineering - Engenharia Química

Palavras-chave

• Schiff base
• Indole-3-carboxaldehyde
• Molecular docking
• Anticancer
• Zirconium(IV)

eng - Inglês