Article In: orcid
A multifunctional Schiff base: investigating its Zirconium sensing capabilities and antiproliferative effects
Journal of Molecular Structure
— 2026 — Elsevier
Key information
Authors:
Published in
January 2026
Abstract
The current investigation is focused on the synthesis of indole-3-carboxaldehyde functionalized Schiff base 5, which was characterized via X-ray crystallographic study, 1H NMR spectroscopy, 13C NMR spectroscopy, FT-IR spectroscopy, mass spectrometry (LCMS) and thermal gravimetric analysis (TGA). Compound 5 has been identified as an effective and highly selective Zr(IV) sensor using UV–Visible spectroscopy with a limit of detection (LOD) 3.7 × 10–7 M. Compound 5 exhibited the most significant anticancer activity, reducing cell viability by upto 67.67 % compared to untreated control cells. Experiments on Cajanus cajan (pigeon pea) seeds revealed its efficacy as a good plant growth regulator. Molecular docking studies further supported its therapeutic potential by revealing strong interactions with both an anticancer target protein and a plant gibberellin protein, indicating its dual role as potential anticancer agent and a plant growth regulator. The findings from the study provides the foundation for future research into zirconium sensing and anticancer applications, potentially leading to the development of new sensors and anticancer drugs.
Publication details
Authors in the community:
Brij Mohan
ist429533
Publisher
Elsevier
Link to the publisher's version
https://www.sciencedirect.com/science/article/pii/S002228602502695X?via%3Dihub
Title of the publication container
Journal of Molecular Structure
Volume
1350
Fields of Science and Technology (FOS)
chemical-engineering - Chemical engineering
Keywords
- Schiff base
- Indole-3-carboxaldehyde
- Molecular docking
- Anticancer
- Zirconium(IV)
Publication language (ISO code)
eng - English
Rights type:
Open access