Plant Extract Counteracts Detrimental Effects of Cellular Senescence in Human Skin Fibroblasts

21/11/2016

Cellular senescence is an integrate part of aging, being one of the main promoters of age-related diseases. Senescence is responsible for encouraging dysfunction, atrophy and chronic inflammation that wear down any tissue with age. However, it exhibits essential benefits, such as suppressing tumor development, which make it more difficult to develop strategies to tackle senescence. When allied with the Papillary-to-Reticular Transition hypothesis, both these cellular events describe the human dermal fibroblast process of aging in skin. A plant extract, named 1201, was evaluated in challenging fibroblast senescence, by several approaches. Also, more justification for the papillary-to-reticular transition hypothesis was searched. 1201 is the first reported concoction that can go against senescence in three different ways. Firstly, 1201 was shown to delay senescence by interfering in the papillary-to-reticular transition. Secondly, it was proven to cripple the secretory phenotype of senescent fibroblasts. Finally, abilities in selectively eliminating senescent cells were verified. Together, 1201 demonstrated considerable potential in being an all-round force against senescence in skin.

Autores da comunidade :

• 

  A

  André Dargen de Matos Branco

  ist172930

  Afiliações e fontes

  De: cienciavitae

  ID: 3298876

Orientadores desta instituição:

• 

  T

  Tiago Paulo Gonçalves Fernandes

  ist147740

- Biotecnologia Industrial

- Inglês

Instituto Superior Técnico